The Science Behind PDGF Under the Eyes

September 23, 2025

Dark circles, fine lines, and crepey texture under the eyes are among the most common concerns patients bring to us. While fillers, lasers, and topicals all play a role, there’s one regenerative ingredient that stands out in skin science: PDGF (Platelet-Derived Growth Factor).

What is PDGF?

PDGF is a naturally occurring protein in the body that plays a vital role in wound healing and tissue regeneration. Think of it as a cellular messenger—it signals your skin cells to activate repair, stimulate collagen production, and recruit other growth factors to the area.

When applied or injected strategically under the eyes, PDGF works at the cellular level to restore strength and thicknessto fragile under-eye skin. Instead of simply masking issues, it helps rebuild healthier skin from within.

Why the Under-Eye Area Needs Extra Help

The skin under your eyes is the thinnest on your body—up to five times thinner than the skin on your cheeks. With age, sun exposure, and lifestyle stressors, this delicate tissue loses collagen, elastin, and circulation. The result:

Hollowness and shadowing
Fine lines and wrinkles
A crepey, fragile texture

Because the under-eye area is so thin, it shows signs of aging earlier and more dramatically. That’s where PDGF makes an impact.

How PDGF Works Under the Eyes

Stimulates Fibroblasts: PDGF “wakes up” the skin’s fibroblast cells, encouraging them to make fresh collagen and elastin.
Improves Microcirculation: By promoting the growth of tiny new blood vessels (angiogenesis), PDGF can enhance oxygen and nutrient delivery, reducing dullness and shadows.
Thickens and Strengthens Skin: Over time, this regenerative activity builds a firmer, healthier dermal layer, making the under-eye less translucent and more resilient.
Pairs Well with Other Treatments: PDGF can be layered with lasers, microneedling, or fillers to speed healing and amplify results.

Clinical Benefits Patients Notice

Softer fine lines and wrinkles
Less visible hollows and darkness
A smoother, more rested appearance
Longer-lasting results when combined with other treatments

The Bottom Line

While eye creams and concealers may provide quick cover-ups, PDGF takes a scientific, regenerative approach to restoring under-eye skin. By addressing the root causes of thinning, fragile tissue, it helps you achieve results that look refreshed and natural—without relying solely on filler or camouflage. Visit our walk-in clinic today!